Melatonin and clinical application

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Melatonin and clinical application.

A review of the different publications dealing with melatonin in humans shows that this field has been very active in the last few years. Normative melatonin values have been defined. Various relationships between melatonin and other traits have been studied, such as sleep, circadian rhythm, surgical stress and anaesthesia. Age-related melatonin studies and melatonin during depression and other...

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Melatonin, its agonists in pain modulation: clinical application

Melatonin (N-acetyl-5-methoxytryptamine) is a hormone secreted by the pineal gland of all animals as well as in human beings. It is not only synthesized in the pineal gland but also many other organs like eye (Cardinali and rosner, 1971), gastro-intestinal tract (Bubenik, 2002), skin (Slominiski, 2005), lymphocytes (Carrillo-Vico et al., 2004), thymus (Naranjo et al., 2007) etc. Besides being a...

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Melatonin: therapeutic and clinical utilization.

Melatonin, acting through melatonin receptors, is involved in numerous physiological processes including circadian entrainment, blood pressure regulation, oncogenesis, retinal physiology, seasonal reproduction, ovarian physiology, immune function and most recently in inducing osteoblast differentiation. Moreover, melatonin was proved to be a potent-free radical scavenger and a broad-spectrum an...

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Melatonin and its agonists in pain modulation and its clinical application.

Melatonin, the hormone of darkness has many physiological functions in the body and also exerts a number of pharmacological effects. Most of these actions of melatonin are mediated through melatonin membrane receptors like MT1/MT2 receptors or through nuclear orphan receptors like RZR/ROR receptors or through calcium binding proteins in the cytosol. The finding that pain perception is circadian...

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Physiology and clinical use of melatonin Author

Author Richard Wurtman, MD Cecil H Green Distinguished Professor Department of Brain and Cognitive Sciences Massachusetts Institute of Technology Disclosures: Consultant/Advisory Boards: Danone Medical Foods (Alzheimer's disease); Centre Int'l Research Servier (pain, personalized medicine). Patent Holder: Back Bay Scientific (medical uses of nutrients (inventor, patents held by MIT)). Section E...

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ژورنال

عنوان ژورنال: Reproduction Nutrition Development

سال: 1999

ISSN: 0926-5287

DOI: 10.1051/rnd:19990309